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Latest News Feeds From the
Nature
Nature Clinical Practice Cardiovascular Medicine - AOP
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Nature Reviews Cardiology - AOP - nature.com science feeds
Nature Reviews Cardiology provides physicians and academics with authoritative and topical discussions of key developments in the field.
Regulatory mechanisms in vascular calcification
by Andrew P. SageYin TintutLinda L. Demer
27 Jul 2010 at 12:00am
Vascular calcification is associated with an increased risk of cardiovascular and all-cause mortality. In the past decade, the prevalence, significance, and regulatory mechanisms of vascular calcification have gained increasing recognition. In this Review, Drs Sage, Tintut and Demer discuss our knowledge of the regulatory mechanisms for both atherosclerotic and medial calcification.
Acute pulmonary embolism. Part 1: epidemiology and diagnosis
by Renée A. DoumaPieter W. KamphuisenHarry R. Büller
20 Jul 2010 at 12:00am
Pulmonary embolism (PE) is a frequently occurring, acute, and potentially fatal condition. Numerous risk factors for PE have been identified. The diagnostic work-up for PE should comprise safe, efficient and noninvasive methods. In this Review, Renée Douma and colleagues discuss the epidemiology of PE, its risk factors and clinical presentation, together with the latest advances in the diagnostic approach to this condition.
Epigenetics and cardiovascular disease
by José M. OrdovásCaren E. Smith
6 Jul 2010 at 12:00am
Epigenetic modifications, such as DNA methylation and histone acetylation, are crucial for homeostasis, and enable cells to respond quickly to environmental changes. However, epigenetic alterations are also associated with the development and progression of disease. The authors of this Review outline how epigenetics may contribute to cardiovascular disease, and highlight potential therapeutic agents that modify the epigenetic state, which could be used in the prevention or treatment of cardiovascular disease.
New antithrombotic agents?insights from clinical trials
by Jeremy S. PaikinJohn W. EikelboomJohn A. CairnsJack Hirsh
29 Jun 2010 at 12:00am
Antithrombotic therapy with ADP-receptor antagonists or anticoagulant agents improves outcomes in patients with acute coronary syndromes and/or undergoing percutaneous coronary intervention. However, the current standard-of-care ADP-receptor antagonist for dual antiplatelet therapy, clopidogrel, and the currently available oral anticoagulants, the coumarins, have several limitations. In this Review, the authors discuss the pharmacology and clinical potential of new antithrombotic drugs, with an emphasis on data from phase III clinical trials.
Four decades of Fontan palliation
by Marc R. de LevalJohn E. Deanfield
29 Jun 2010 at 12:00am
The Fontan palliation was introduced in 1968 for congenital heart defects with a single dominant ventricle. Although considerable technical improvements have meant that this procedure can be applied to a wide range of patients, the Fontan circulation has intrinsic limitations. Professors de Leval and Deanfield consider the past four decades of Fontan palliation and describe how developments have moved practice closer to the 'perfect' Fontan. Future challenges and possible solutions are also discussed.
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